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Completely, our info offer evidence with the likely of mixing CX-5461 and PARPi for strengthening the therapy of HR-deficient HGSOC. We reveal that CX-5461 boosts the artificial lethal conversation of PARPi with HRD and Plainly exhibit that CX-5461 has a different system of motion to PARPi. Importantly, we characterized BRCA-mutated and MYC targets